Development of Quantum Algorithms on Graphs and for Quantum Markov Models.
Quantum algorithms for choice modeling.
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We are a research group based in Xanthi Greece, operating within the Department of Electrical and Computer Engineering at the Democritus University of Thrace. Our mission is to advance the field of quantum computing through both foundational and applied research.
Our work focuses on key areas including quantum walks, game theory, quantum machine learning, and quantum optimization. By adopting a multidisciplinary approach, we aim to contribute to the development of quantum technologies and to explore their potential impact on computation, decision-making processes, and complex systems.
Beyond our research activities, we are committed to education and academic development. Our team plays an active role in the department’s undergraduate curriculum, introducing students to the fundamentals of Quantum Information and Quantum Computation. Moreover, our group co-organized the International M.Sc. Program in Quantum Computing and Quantum Technologies, with our lab’s head, Prof. Karafyllidis, serving as the program director. This initiative strengthens our commitment to nurturing the next generation of quantum scientists and engineers.
Our team
Ioannis Karafyllidis
Professor
Georgios Varsamis
PhD Candidate
Ioannis Liliopoulos
PhD Candidate
Projects
Ongoing
Empowering Europe’s Data Future.
A catalyst for European Cloud-Services in the era of data spaces, high-performance and edge computing.
Former
Study, design, development and implementation of a holistic system for upgrading the quality of life and activity of the elderly.
Development of Quantum algorithms for DNA sequencing.
Introduction of quantized reference guided and de-novo methods.
Quantum Computing approach to accelerate ligand docking and screening in the drug design process.
Algotithms for quantum machine learning.
Hybrid quantum classical neural network framework with apllications in agricalture and sustainability.Quantum games.
Scalable quantized version of multiplayer and proxy zero-sum cooperative games.
Publications
2025
Rallis, K., Liliopoulos, I., Varsamis, G.D., Tsipas, E., Karafyllidis, I.G., Sirakoulis, G.C., Dimitrakis, P., 2025b. Interfacing Quantum Computing Systems with High-Performance Computing Systems: An Overview. https://doi.org/10.48550/arXiv.2509.06205
Varsamis, G.D., Liliopoulos, I., Mohammadbagherpoor, H., Kostopoulos, A.K., Milchanowski, K., Karamatskos, E.T., Dimitrakis, P., Padbury, R.P., Karafyllidis, I.G., n.d. Analysis of the Effect of Entanglement Operators and the Scalability of Players’ Payoff Computation in N-Player Quantum Games. Advanced Quantum Technologies n/a, e00375. https://doi.org/10.1002/qute.202500375
Rallis, K., Liliopoulos, I., Tsipas, E., Varsamis, G.D., Melissourgos, N., Karafyllidis, I.G., Sirakoulis, G.C., Dimitrakis, P., 2025a. Hardware-level Interfaces for Hybrid Quantum-Classical Computing Systems, in: 2025 6th International Conference in Electronic Engineering & Information Technology (EEITE). pp. 1–6. https://doi.org/10.1109/EEITE65381.2025.11166221
Liliopoulos, I., Varsamis, G.D., Karamanidou, T., Papalitsas, C., Koulouras, G., Pantazopoulos, V., Stavropoulos, T.G., Karafyllidis, I.G., 2025a. Quantum algorithm for protein-ligand docking sites identification in the interaction space. J Comput Aided Mol Des 39, 40. https://doi.org/10.1007/s10822-025-00620-5
Liliopoulos, I., Varsamis, G.D., Karafyllidis, I.G., 2025. Quantum Cellular Automata, in: Adamatzky, A., Sirakoulis, G.Ch., Martinez, G.J. (Eds.), Advances in Cellular Automata: Volume 2: Computation and Applications. Springer Nature Switzerland, Cham, pp. 71–105. https://doi.org/10.1007/978-3-031-81097-8_4
Liliopoulos, I., Varsamis, G.D., Milchanowski, K., Martin‑Cuevas, R., Safouri, K., Dimitrakis, P., Karafyllidis, I.G., 2025b. Hybrid classical-quantum multilayer neural networks for monitoring agricultural activities using remote sensing data. Quantum Mach. Intell. 7, 4. https://doi.org/10.1007/s42484-024-00230-8
2024
Liliopoulos, I., Varsamis, G.D., Karafyllidis, I.G., 2024. Discrete-time quantum walk-based optimization algorithm. Quantum Inf Process 23, 23. https://doi.org/10.1007/s11128-023-04234-4
2023
Varsamis, G. D., Karafyllidis, I.G., Gilkes, K.M., Arranz, U., Martin-Cuevas, R., Calleja, G., Dimitrakis, P., Kolovos, P., Sandaltzopoulos, R., Jessen, H.C., Wong, J., 2023a. Quantum gate algorithm for reference-guided DNA sequence alignment. Computational Biology and Chemistry 107, 107959. https://doi.org/10.1016/j.compbiolchem.2023.107959
Varsamis, G. D., Karafyllidis, I.G., Gilkes, K.M., Arranz, U., Martin-Cuevas, R., Calleja, G., Wong, J., Jessen, H.C., Dimitrakis, P., Kolovos, P., Sandaltzopoulos, R., 2023b. Quantum algorithm for de novo DNA sequence assembly based on quantum walks on graphs. Biosystems 233, 105037. https://doi.org/10.1016/j.biosystems.2023.105037
Varsamis, G.D., Karafyllidis, I.G., 2023. A quantum walks assisted algorithm for peptide and protein folding prediction. Biosystems 223, 104822. https://doi.org/10.1016/j.biosystems.2022.104822
Varsamis, Georgios D., Karafyllidis, I.G., Sirakoulis, G.Ch., 2023. Quantum walks in spaces with applied potentials. Eur. Phys. J. Plus 138, 312. https://doi.org/10.1140/epjp/s13360-023-03921-6
2022
Varsamis, G.D., Karafyllidis, I.G., Sirakoulis, G.Ch., 2022. Hitting times of quantum and classical random walks in potential spaces. Physica A: Statistical Mechanics and its Applications 606, 128119. https://doi.org/10.1016/j.physa.2022.128119
Varsamis, G.D., Karafyllidis, I.G., 2022. Computing the lowest eigenstate of tight-binding Hamiltonians using quantum walks. Int. J. Quantum Inform. 20, 2250012. https://doi.org/10.1142/S0219749922500125
2021
Fyrigos, I.-A., Ntinas, V., Vasileiadis, N., Sirakoulis, G.Ch., Dimitrakis, P., Zhang, Y., Karafyllidis, I.G., 2022. Memristor Crossbar Arrays Performing Quantum Algorithms. IEEE Transactions on Circuits and Systems I: Regular Papers 69, 552–563. https://doi.org/10.1109/TCSI.2021.3123575
Fyrigos, I.-A., Chatzinikolaou, T.P., Ntinas, V., Vasileiadis, N., Dimitrakis, P., Karafyllidis, I., Sirakoulis, G.Ch., 2021a. Memristor Crossbar Design Framework for Quantum Computing, in: 2021 IEEE International Symposium on Circuits and Systems (ISCAS). Presented at the 2021 IEEE International Symposium on Circuits and Systems (ISCAS), pp. 1–5. https://doi.org/10.1109/ISCAS51556.2021.9401581
Fyrigos, I.-A., Ntinas, V., Sirakoulis, G.Ch., Dimitrakis, P., Karafyllidis, I.G., 2021b. Quantum Mechanical Model for Filament Formation in Metal-Insulator-Metal Memristors. IEEE Transactions on Nanotechnology 20, 113–122. https://doi.org/10.1109/TNANO.2021.3049632
2010 – 2019
Karafyllidis, I.G., Sirakoulis, G.Ch., Dimitrakis, P., 2019. Memristive Quantum Computing Simulator. IEEE Transactions on Nanotechnology 18, 1015–1022. https://doi.org/10.1109/TNANO.2019.2941763
Karafyllidis, I.G., Sirakoulis, G.Ch., 2018. Quantum Walks on Quantum Cellular Automata Lattices: Towards a New Model for Quantum Computation, in: Mauri, G., El Yacoubi, S., Dennunzio, A., Nishinari, K., Manzoni, L. (Eds.), Cellular Automata. Springer International Publishing, Cham, pp. 319–327. https://doi.org/10.1007/978-3-319-99813-8_29
Karafyllidis, I.G., 2017. Quantum transport in the FMO photosynthetic light-harvesting complex. J Biol Phys 43, 239–245. https://doi.org/10.1007/s10867-017-9449-4
Karafyllidis, I.G., 2015. Quantum walks on graphene nanoribbons using quantum gates as coins. Journal of Computational Science 11, 326–330. https://doi.org/10.1016/j.jocs.2015.05.006
Karafyllidis, I.G., Hagouel, P.I., 2014. MULTIPLE QUANTUM WALKERS ON THE LINE USING HYBRID COINS: A POSSIBLE TOOL FOR QUANTUM SEARCH. Facta Universitatis, Series: Electronics and Energetics 27, 103–112.
Tsormpatzoglou, G.I., Karafyllidis, I.G., 2012. Periodicity in Quantum Cellular Automata, in: Sirakoulis, G.Ch., Bandini, S. (Eds.), Cellular Automata, Lecture Notes in Computer Science. Springer Berlin Heidelberg, Berlin, Heidelberg, pp. 585–590. https://doi.org/10.1007/978-3-642-33350-7_60
Hagouel, P.I., Karafyllidis, I.G., 2012. Quantum computers: Registers, gates and algorithms, in: 2012 28th International Conference on Microelectronics Proceedings. Presented at the 2012 28th International Conference on Microelectronics, pp. 15–21. https://doi.org/10.1109/MIEL.2012.6222789
2000 – 2009
Vlachos, P., Karafyllidis, I.G., 2009b. Quantum game simulator, using the circuit model of quantum computation. Computer Physics Communications 180, 1990–1998. https://doi.org/10.1016/j.cpc.2009.05.007
Panagiotis, V., Karafyllidis, I., 2009. Quantum Game Simulator, Using the Circuit Model of Quantum, in: 2009 13th Panhellenic Conference on Informatics. Presented at the 2009 13th Panhellenic Conference on Informatics, pp. 220–224. https://doi.org/10.1109/PCI.2009.46
Mardiris, V.A., Karafyllidis, I.G., 2009. Universal cellular automaton cell using quantum cellular automata. Electronics Letters 45, 607–609. https://doi.org/10.1049/el.2009.3693
Vlachos, P., Karafyllidis, I.G., 2009a. Simulation of quantum key expansion using quantum cellular automata. Computer Physics Communications 180, 251–255. https://doi.org/10.1016/j.cpc.2008.10.002
Karafyllidis, I.G., 2008. Quantum mechanical model for information transfer from DNA to protein. Biosystems 93, 191–198. https://doi.org/10.1016/j.biosystems.2008.04.002
Karafyllidis, I.G., 2005. Quantum computer simulator based on the circuit model of quantum computation. IEEE Transactions on Circuits and Systems I: Regular Papers 52, 1590–1596. https://doi.org/10.1109/TCSI.2005.851999
Contact us
Department of Electrical and Computer Engineeirng
Democritus University of Thrace
Address: Building A, University Campus Kimmeria, Xanthi, 67100, Greece
Tel.: (+30) 2541079548
Email: ykar@ee.duth.gr
